Sodium bis(trimethylsilyl)amide
- Product Name
- Sodium bis(trimethylsilyl)amide
- CAS No.
- 1070-89-9
- Chemical Name
- Sodium bis(trimethylsilyl)amide
- Synonyms
- NAHMDS;SODIUM HEXAMETHYLDISILAZANE;SODIUM HEXAMETHYLDISILAZIDE;Sodium Bis(trimethylsilyl)amide, 1M THF;HMDS Na;N-SODIOHEXAMETHYLDISILAZANE;Sodiobis(trimethylsilyl)amine;sodium bis(trimethylsilyl)amide solution;HMN NA SALT;sodiumbis(tri
- CBNumber
- CB8382263
- Molecular Formula
- C6H18NNaSi2
- Formula Weight
- 183.37
- MOL File
- 1070-89-9.mol
Sodium bis(trimethylsilyl)amide Property
- Melting point:
- 171-175 °C (lit.)
- Boiling point:
- 67°C
- Density
- 0.904 g/mL at 25 °C
- Flash point:
- 43 °F
- storage temp.
- 2-8°C
- solubility
- Soluble in hexane, toluene, ether,terahydrofuran, benzene and toluene.
- form
- Liquid
- Specific Gravity
- 0.9
- color
- Clear orange to brown
- Water Solubility
- reacts
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- Sensitive
- Moisture Sensitive
- BRN
- 3629917
- Exposure limits
- ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) - CAS DataBase Reference
- 1070-89-9(CAS DataBase Reference)
- EPA Substance Registry System
- Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1070-89-9)
Safety
- Hazard Codes
- C,F
- Risk Statements
- 14-34-19-11-67-65-63-48/20-14/15-40-37
- Safety Statements
- 26-45-62-36/37/39-33-16-43-8
- RIDADR
- UN 3263 8/PG 2
- WGK Germany
- 3
- F
- 10-21
- TSCA
- Yes
- HazardClass
- 4.3
- PackingGroup
- III
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 245585
- Product name
- Sodium bis(trimethylsilyl)amide solution
- Purity
- 1.0?M in THF
- Packaging
- 100ML
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 80631
- Product name
- Sodium bis(trimethylsilyl)amide solution
- Purity
- produced by Wacker Chemie AG, Burghausen, Germany, 40% in THF
- Packaging
- 500mL
- Price
- $200
- Updated
- 2024/03/01
- Product number
- 245585
- Product name
- Sodium bis(trimethylsilyl)amide solution
- Purity
- 1.0?M in THF
- Packaging
- 800ML
- Price
- $287
- Updated
- 2024/03/01
- Product number
- 235083
- Product name
- Sodium bis(trimethylsilyl)amide
- Purity
- 95%
- Packaging
- 5g
- Price
- $105
- Updated
- 2023/06/20
- Product number
- 235083
- Product name
- Sodium bis(trimethylsilyl)amide
- Purity
- 95%
- Packaging
- 25g
- Price
- $115
- Updated
- 2023/06/20
Sodium bis(trimethylsilyl)amide Chemical Properties,Usage,Production
Chemical Properties
Slightly yellow to light beige crystalline powder
Physical properties
mp 171–175 °C; bp 170 °C/2 mmHg.
Uses
It is a strong base; deprotonates ketones and esters to generate enolate derivative.
Uses
Sodium bis(trimethylsilyl)amide is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, it has been used as a nitrogen source for the preparation of primary amines.It is useful as a sterically hindered base and as a nucleophile.
Uses
Significantly accelerated the polymerization of pheneylacetylene in conjunction with rhodium (I) catalysis
General Description
Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.
Purification Methods
It can be sublimed at 170o/2mm (bath temperature 220-250o) onto a cold finger, and can be recrystallised from *C6H6 (its solubility is: 10g in 100mL at 60o). It is slightly soluble in Et2O and is decomposed by H2O. [Wannagat & Niederprüm Chem Ber 94 1540 1961.]It is available commercially under N2 in Sure/Seal bottles in tetrahydrofuran (various concentrations) and at ~0.6M in toluene. [Beilstein 4 IV 4014.]
Sodium bis(trimethylsilyl)amide Preparation Products And Raw materials
Raw materials
Preparation Products
Sodium bis(trimethylsilyl)amide Suppliers
- Tel
- +44 (0) 1928 579865
- Fax
- +44 (0) 1928 579734
- andrew.freer@syntor.co.uk
- Country
- United Kingdom
- ProdList
- 99
- Advantage
- 60
View Lastest Price from Sodium bis(trimethylsilyl)amide manufacturers
- Product
- Sodium bis(trimethylsilyl)amide 1070-89-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-03-25
- Product
- Sodium bis(trimethylsilyl)amide 1070-89-9
- Price
- US $6.00-0.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-18
- Product
- Sodium bis(trimethylsilyl)amide 1070-89-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-29